Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.
In over just 30 years, Eurofins has grown from one laboratory in Nantes, France to over 50,000 staff across a network of more than 900 independent companies in over 50 countries and operating more than 800 laboratories. Eurofins offers a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products, as well as providing innovative clinical diagnostic testing services, as one of the leading global emerging players in specialised clinical diagnostics testing.
In 2019, Eurofins generatedtotal revenues of EUR € 4.56 billion, and has been among the best performing stocks in Europe over the past 20 years.
The successful candidate will lead analytical assay support for the mRNA therapeutic Process Development group based in Chesterfield, MO.
This group is responsible for developing robust processes for the generation of RNA therapeutics. These RNA molecules are chosen by the vaccine research unit as candidates for the treatment in multiple therapeutic areas. The processes developed by the mRNA process development group are used in GMP manufacturing facilities to produce the RNA in large quantities for clinical and commercial needs.
The RNA production process involves in-vitro transcription of plasmid DNA, purification and filtration. Characterization of in-process samples are required in developing, scaling and optimizing the RNA manufacturing processes. The successful candidate will drive the analytical support to the team by performing analytical testing on in-process samples.
Job Responsibilities and Requirements:
The successful candidate will drive analytical support efforts for the GTx process development group - receiving and managing samples, performing required analytical tests, processing the data and providing data summaries back to the responsible scientists.
Applicant would be providing in-process analytical support as part of an mRNA therapeutic process development team. The candidate should be skilled in analyzing low concentration, large biomolecules (ideally RNA and DNA) with specific training in HPLC, Gel Electrophoresis, Capillary gel electrophoresis (CGE). Familiarity with Agilent HPLC instruments (Both Empower and Open Lab software) preferred. Experience with mRNA handling technique, other analytical techniques (rheometry, SEC-MALS, DLS, qPCR, ddPCR), and the use of automatic liquid handlers for analytical sample prep and the use of data analysis software (Excel, Spotfire) would also be beneficial.
General requirements include performing data analysis using Microsoft Excel, composing scientific documents for electronic lab notebooks, and maintenance of experimental data in relevant electronic databases. Strong organizational skills and a readiness to support a safe working environment are also required.