Research Fellow
Massachusetts General Hospital(MGH)

Job Description:

The Sachdeva Lab at Massachusetts General Hospital is seeking a highly motivated postdoctoral research fellow interested in pursuing scientific investigations into the molecular pathogenesis of esophageal cancer. Esophageal cancer is the eighth most common malignancy worldwide, with a 5-year survival of approximately 20%. Our lab studies both esophageal adenocarcinoma and squamous cell carcinoma, with a particular focus on the how the benign condition of Barrett's esophagus undergoes malignant degeneration into adenocarcinoma, and the role of the tumor microenvironment in this process.

Duties and Responsibilities:

The fellow will join a dynamic young laboratory led by an early-career surgeon-scientist studying the basic and translational biology of esophageal cancers. This lab is comprised of excited and innovative young scientists and trainees building the projects in this space as a novel area of study within the Division of Thoracic Surgery at MGH. Collectively, the Thoracic Surgery Laboratories form a collaborative group of scientists with expertise in multiple thoracic malignancies and tissue regeneration, creating a vibrant scientific environment. This research will focus on 3D culture models of esophageal cancer and pre-malignant conditions using human-derived organoids and animal models. This position provides outstanding opportunities for continued scientific development and pioneering research with high translational impact. The candidate will be responsible for leading projects within the laboratory, designing and conducting independent experiments, data analysis, manuscript preparation, and supervising trainees towards completion of the project aims. Proficiency in cellular and molecular biology techniques, leadership skills, initiative, and independence will be essential for the successful candidate. The PI is committed to mentorship of the candidate towards future career goals.

Qualifications
Job Requirements:

The candidate will have a strong foundation in experimental research with a robust record of publication. A PhD or MD degree is required. Expertise in molecular and cellular biology is necessary, including proficiency with tissue culture, protein and gene expression analyses, and cell-based genetic knockdown and overexpression techniques. Experience in techniques of flow cytometry, CRISPR-based genomic modulation, 3D organoid culture, and/or rodent xenograft models are particularly beneficial but not required. Outstanding oral and written communication skills and proficiency with the English language are essential.

Please include a cover letter with your resume.

EEO Statement
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.

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