Senior Scientist, TTD
AstraZeneca

Senior Scientist, TTD

Are you ready to make a significant impact in the field of oncology research? We are seeking a highly motivated Senior Scientist in Targeted Tumor Delivery (TTD) with a strong scientific and technical expertise! This role is based in our Oncology R&D department in Waltham, MA USA. You will be a key member of a team focused on supporting oncology projects through the drug discovery and development process. Your theoretical and practical expertise in cancer biology will be instrumental in establishing assay systems and delivering datasets that will have a direct impact on targeted therapeutics.

Accountabilities:

In this role, you will design, conduct, and analyze in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel therapeutics. You will also review emerging literature and internal data to identify new targets and contribute to target validation activities.

Essential Skills/Experience:

• MS degree in Biomedical Sciences, Oncology, Pharmacology or a related field and 5+ years experience in pharmaceutical drug development

• Robust, hands-on experience (>3 years) evaluating antibody drug conjugates in cell-based assays (such as binding, internalization, viability, etc)

• Experience in a range of in vitro skills for the analysis of human tumor cell function (e.g. cell culture, cell signaling bioassays, high-content imaging, and cell death measurement)

• Experience in independently developing assays to assess ADC pharmacology in in vitro assays

• Experience with managing relationships with external vendors to ensure timely delivery of outsourced requests

• Works equally well independently and in collaboration to execute assigned tasks in a manner consistent with project goals

• Strong interpersonal and collaboration skills

• Demonstrated scientific rigor and excellence with first-author disclosures (e.g. conference abstracts, publications)

At AstraZeneca, we are on a mission to eliminate cancer as a cause of death. We are a science-based, leading and decisive Oncology enterprise united in our vision. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.

Are you ready to join us on this mission? Apply today and help us push the boundaries of science to change the practice of medicine!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.